It is possible to set properties for the JDBC driver on specific instances.
You can find this under “Advanced Driver Setup” in the Add instance wizard, or under “Edit parameters” in the JDBC panel in the Configure instance dialog.
The driver properties dialog looks like this.
The properties you set here will be applied to the JDBC connection on the database. The example above will enable network encryption for an oracle instance.
See documentation from the specific dbms platform for legal properties to set on the connection.